M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Synonym(s): 3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
• Empirical Formula (Hill Notation): C₄H₆N₂O₂
• CAS Number: 2763-96-4
• Molecular Weight: 114.10
• Beilstein: 1618960
• EC Number: 220-430-4
• MDL number: MFCD00057894
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896662
• NACRES: NA.77

Properties

• product name: Muscimol, powder
• form: powder
• Quality Level: 200
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
• InChI key: ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Gene Information: rat ... Gabra2(29706)

Description

General description

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Application

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Biochem/physiol Actions

GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300,H336
• Precautionary Statements: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Oral - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves