P6500

Pentylenetetrazole

≥99% (GC), powder, CNS stimulant

• Synonym(s): α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
• Empirical Formula (Hill Notation): C₆H₁₀N₄
• CAS Number: 54-95-5
• Molecular Weight: 138.17
• EC Number: 200-219-3
• MDL number: MFCD00005939
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278643
• NACRES: NA.77

Properties

• product name: Pentylenetetrazole,
• form: powder
• bp: 194 °C/12 mmHg (lit.)
• mp: 59-61 °C (lit.)
• storage temp.: −20°C
• SMILES string: C1CCc2nnnn2CC1
• InChI: 1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
• InChI key: CWRVKFFCRWGWCS-UHFFFAOYSA-N

Description

General description

Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier.

Application

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Biochem/physiol Actions

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H335
• Precautionary Statements: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves