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Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines.

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines.

Chemical communications (Cambridge, England) (2013-01-12)

Xuejian Li, Yanyan Zhao, Haijun Qu, Zhenjun Mao, Xufeng Lin

要旨

The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.

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製品内容

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リン酸, ACS reagent, ≥85 wt. % in H₂O

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リン酸, 85 wt. % in H₂O, 99.99% trace metals basis

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リン酸, ACS reagent, ≥85 wt. % in H₂O

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リン酸, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥85%

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リン酸, crystalline, ≥99.999% trace metals basis

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リン酸, puriss. p.a., crystallized, ≥99.0% (T)

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リン酸, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, 85.0-88.0%

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アニリン, ACS reagent, ≥99.5%

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リン酸, ≥85 wt. % in H₂O, ≥99.999% trace metals basis

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アニリン溶液, certified reference material, 5000 μg/mL in methanol

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