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product name
Discovery®Cyano HPLCカラム, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
物質
stainless steel column
品質水準
認証
suitable for USP L10
製品種目
Discovery®
特徴
endcapped
メーカー／製品名
Discovery®
包装
1 ea of
標識化の程度
4.5% Carbon loading
パラメーター
≤70 °C temp. range
400 bar pressure (5801 psi)
テクニック
HPLC: suitable
LC/MS: suitable
L × 内径
25 cm × 4.6 mm
表面積
200 m2/g
表面被覆率
3.5 μmol/m2
不純物
<10 ppm metals
マトリックス
silica gel, high purity, spherical base material
fully porous particle
マトリックス活性基
cyano phase
粒径
5 μm
ポアサイズ
180 Å
operating pH range
2-8
アプリケーション
food and beverages
分離法
hydrophilic interaction (HILIC)
normal phase
reversed phase
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関連するカテゴリー
特徴および利点
- 疎水性分析対象物の迅速な溶出に要する疎水性の低さ
- 優れたピ-ク形状および強塩基性分析対象物の保持
- 極性分析対象物の保持
- 独自の選択性
- C18カラムよりも顕著に低い保持(低濃度の有機系移動相が必要)
- 安定で低ブリ-ドのLC-MS分離
- 水系有機溶媒の濃度が高い移動相で使用可能
法的情報
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade
Aleem Gangjee et al.
Journal of medicinal chemistry, 53(22), 8116-8128 (2010-10-27)
Two classes of molecules were designed and synthesized based on a 6-CH(3) cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in turn was chlorinated and reacted with the appropriate anilines to
Xuqing Zhang et al.
Journal of medicinal chemistry, 50(16), 3857-3869 (2007-07-20)
A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R1 to R6 positions as well as the core pyrazoline ring
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
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