T8024

テトロドトキシン

≥98% (HPLC), powder

• 別名: TTX, タリカトキシン, フグ毒, マクロトキシン
• 実験式（ヒル表記法）: C₁₁H₁₇N₃O₈
• CAS番号: 4368-28-9
• 分子量: 319.27
• EC Number: 224-458-8
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900493
• Beilstein/REAXYS Number: 49176
• MDL number: MFCD00213719

特性

• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.), strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• storage temp.: 2-8°C
• SMILES string: [H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• InChI key: CFMYXEVWODSLAX-IXUBDLNJSA-N
• Gene Information: rat ... Scnn1g(24768)

詳細

Application

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca²⁺ currents in rat hippocampal interneurons.

Biochem/physiol Actions

Na⁺チャネルの選択的かつ可逆的なブロッカ-であり、興奮性膜の活動電位の伝播を遮断します。興奮性膜のナトリウムチャネルの特定や、生理的正常状態および疾患におけるナトリウムチャネルの役割の研究に用いられます。

Na⁺チャネルの選択的かつ可逆的なブロッカ-です。

Preparation Note

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

安全性情報

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• 保管分類: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges