T5443

チロホスチンAG 825

≥92.5%

• 別名: 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• 実験式（ヒル表記法）: C₁₉H₁₅N₃O₃S₂
• CAS番号: 149092-50-2
• 分子量: 397.47
• MDL番号: MFCD01074971
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826823
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥92.5%
• 形状: powder
• 溶解性: DMSO: soluble; methanol: soluble
• 保管温度: −20°C
• SMILES記法: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChI Key: KXDONFLNGBQLTN-WUXMJOGZSA-N

詳細

アプリケーション

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

生物化学的／生理学的作用

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

EGF受容体チロシンキナーゼ阻害剤ですが、IGF-1受容体には不活性です。

特徴および利点

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調製ノート

Tyrphostin AG 825 is soluble in DMSO and methanol.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)