SML3492

Chromenone 1

≥98% (HPLC)

• 別名: 2-(1H-1,2,4-Triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one
• 実験式（ヒル表記法）: C₁₈H₁₀F₃N₃O₂
• CAS番号: 1639929-29-5
• 分子量: 357.29
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C1C(C2=CC=C(C=C2)C(F)(F)F)=C(OC3=CC=CC=C13)N4N=CN=C4
• InChI: 1S/C18H10F3N3O2/c19-18(20,21)12-7-5-11(6-8-12)15-16(25)13-3-1-2-4-14(13)26-17(15)24-10-22-9-23-24/h1-10H
• InChI Key: KLOOVUXILKCLLC-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Bone morphogenetic protein (BMP) signaling potentiator that exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition.

Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator that exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4, respectively).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable