SML2812

AN1

≥98% (HPLC)

• 別名: 5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
• 実験式（ヒル表記法）: C₁₅H₉Br₂NO₃
• CAS番号: 486443-73-6
• 分子量: 411.04
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
• InChI: 1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
• InChI Key: GPKLWRHHVIBYEO-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.

brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable