SML2801

Isoforskolin

≥95% (HPLC)

• 別名: 6-Acetyl-7-deacetylforskolin, (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, Coleonol B, 6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one, Isoforskolin
• 実験式（ヒル表記法）: C₂₂H₃₄O₇
• CAS番号: 64657-21-2
• 分子量: 410.50
• MDL番号: MFCD00078929
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 光学活性: [α]/D -8 to -5°, c = 0.5 in chloroform-d
• 色: white to beige
• 溶解性: DMF:H₂O (9:1): 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
• InChI: 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
• InChI Key: CLOQVZCSBYBUPB-VDCUXWMXSA-N

詳細

生物化学的／生理学的作用

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H312
• 注意書き: P280 - P302 + P352 + P312 - P362 + P364 - P501
• 危険有害性の分類: Acute Tox. 4 Dermal
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3