SML2686

THAL-SNS-032

≥98% (HPLC)

• 別名: 4-[[[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1-piperidineacetamide
• 実験式（ヒル表記法）: C₄₀H₅₂N₈O₁₀S₂
• CAS番号: 2139287-33-3
• 分子量: 869.02
• MDL番号: MFCD31689257
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• ligand: pomalidomide
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: [s]1c(ncc1SCc6ncc([o]6)C(C)(C)C)NC(=O)C2CCN(CC2)CC(=O)NCCOCCOCCOCCNc3c4c(ccc3)C(=O)N(C4=O)C5CCC(=O)NC5=O
• InChI: 1S/C40H52N8O10S2/c1-40(2,3)29-21-43-32(58-29)24-59-33-22-44-39(60-33)46-35(51)25-9-13-47(14-10-25)23-31(50)42-12-16-56-18-20-57-19-17-55-15-11-41-27-6-4-5-26-34(27)38(54)48(37(26)53)28-7-8-30(49)45-36(28)52/h4-6,21-22,25,28,41H,7-20,23-24H2,1-3H3,(H,42,50
• InChI Key: BXDZOYLPNAIDOC-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Selective inhibitor and degrader of CDK9

THAL-SNS-032 is a selective inhibitor and degrader of cyclin-dependent kinase 9 (CDK9). It links the CDK inhibitor SNS-032 to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon. THAL-SNS-032 was found to selectively induce degradation of CDK9 over other CDKs. It inhibited proliferation across a panel of 11 different leukemia cancer cell lines potently than SNS-032.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable