SML2658

TT-10

≥98% (HPLC)

• 別名: N2-Allyl-5-[(5-fluorothiophen-2-yl)carbonyl]thiazole-2,4-diamine, TAZ K, TAZ-K, TT 10, [4-Amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)methanone
• 実験式（ヒル表記法）: C₁₁H₁₀FN₃OS₂
• CAS番号: 2230640-94-3
• 分子量: 283.35
• UNSPSCコード: 41106609
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1
• InChI: 1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15)
• InChI Key: GVYPHJQPOHDZEI-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

TAZ activator that promotes cardiomyocytes proliferation by activating YAP/TEAD-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity.

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable