SML1836
β-ODAP
≥98% (HPLC)
別名:
β-N-Oxalo-L-α,β-diaminopropionic acid, β-N-Oxalyl-L-α,β-diaminopropionate, 3-[(Carboxycarbonyl)amino]-L-alanine, BOAA, Dencichin, Dencichine, Nβ-Oxalylamino-L-alanine, ODAP
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5 MG
￥23,200
25 MG
￥74,100
￥23,200
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5 MG
￥23,200
25 MG
￥74,100
About This Item
￥23,200
Check Cart for Availability
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品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
光学活性
[α]/D -17 to -23°, c = 0.5 (Solvent: 4N HCl)
色
white to beige
溶解性
0.1 M HCl: 2 mg/mL, clear (warmed)
保管温度
2-8°C
SMILES記法
OC([C@@H](N)CNC(C(O)=O)=O)=O
InChI
1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)/t2-/m0/s1
InChI Key
NEEQFPMRODQIKX-REOHCLBHSA-N
生物化学的／生理学的作用
β-ODAP is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2) that induces HIF dependent HRE (hypoxia response element) in normoxic conditions. β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors. β-ODAP causes neurolathyrism upon prolonged consumption of L. sativus seeds.
β-ODAP is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2).
β-ODAP is considered more neurotoxic than α-ODAP, thus during food processing, its conversion to α isomer is essential. β-ODAP exhibits its neurotoxicity via the activation of metabotropic glutamatergic receptor.[1]
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals (2012)
Nalini Jammulamadaka et al.
Journal of neurochemistry, 118(2), 176-186 (2011-05-11)
β-N-Oxalyl-L-α,β-diaminopropionic acid (l-ODAP) an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor agonist activates protein kinase C in white leghorn chick brain. The current study focuses on the protein kinase C downstream signaling targets associated with L-ODAP excitotoxicity in SK-N-MC human neuroblastoma cells
Kuniko Kusama-Eguchi et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 67, 113-122 (2014-03-04)
Neurolathyrism is a motor neuron (MN) disease caused by β-N-oxalyl-L-α,β-diaminopropionic acid (L-β-ODAP), an AMPA receptor agonist. L-β-ODAP caused a prolonged rise of intracellular Ca(2+) ([Ca(2+)]i) in rat spinal cord MNs, and the [Ca(2+)]i accumulation was inversely proportional to the MN's
Ravi Kumar Eslavath et al.
European journal of pharmacology, 791, 405-411 (2016-10-30)
Hypoxia inducible factor (HIF)-1α, a subunit of HIF transcription factor, regulates cellular response to hypoxia. In normoxic conditions, it is hydroxylated by prolyl hydroxylase (PHD)-2 and targeted for proteosomal degradation. Drugs which inhibit PHD-2 have implications in conditions arising from
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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