SML1520

GS39783

≥98% (HPLC)

• 別名: N,N′-ジシクロペンチル-2-メチルスルファニル-5-ニトロ-ピリミジン-4,6-ジアミン
• 実験式（ヒル表記法）: C₁₅H₂₃N₅O₂S
• CAS番号: 39069-52-8
• 分子量: 337.44
• MDL番号: MFCD06201849
• UNSPSCコード: 12352202
• PubChem Substance ID: 329825937

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: faintly yellow to dark yellow
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: room temp
• SMILES記法: CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O
• InChI: 1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
• InChI Key: GSGVDKOCBKBMGG-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

GABA_Bレセプタ-に対する正のアロステリックモジュレ-タ-です。

GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H335
• 注意書き: P301 + P312 + P330 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable