SML1449

G3335

≥98% (HPLC)

• 別名: H-Trp-Glu-OH, L-Tryptophyl-L-glutamic acid, WE
• 実験式（ヒル表記法）: C₁₆H₁₉N₃O₅
• CAS番号: 36099-95-3
• 分子量: 333.34
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to off-white
• 保管温度: −20°C
• SMILES記法: [nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2
• InChI: 1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
• InChI Key: PWIQCLSQVQBOQV-AAEUAGOBSA-N

詳細

生物化学的／生理学的作用

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable