SML1346

BRD32048

≥98% (HPLC)

• 別名: BRD 32048, N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine
• 実験式（ヒル表記法）: C₁₆H₂₂N₆O
• CAS番号: 433694-46-3
• 分子量: 314.39
• MDL番号: MFCD03190440
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825802
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: NC1=NC(NC2=CC=C(OC)C=C2)=NC(CN3CCCCC3)=N1
• InChI: 1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21)
• InChI Key: PVHJDJWPRZUURH-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

BRD32048 is a derivative of [1,3,5]triazine. It is found in orally active phosphodiesterase inhibitors (PDE) inhibitors, DHFR (dihydrofolate reductase) inhibitors and phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors. BRD32048 binds ETS variant 1 (ETV1) and controls transcriptional activity, facilitated by ETV1 and invasion of ETV1-driven cancer cells.[1]

BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein.

BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable