SML1177

ML323

≥98% (HPLC)

• 別名: N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
• 実験式（ヒル表記法）: C₂₃H₂₄N₆
• CAS番号: 1572414-83-5
• 分子量: 384.48
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: [n]4(nncc4)c1ccc(cc1)CNc2nc(ncc2C)c3c(cccc3)C(C)C
• InChI: 1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
• InChI Key: VUIRVWPJNKZOSS-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

ML323 induces viral replication in vitro and in vivo. It may act as a potential candidate for the intervention of diseases like rheumatoid arthritis and systemic lupus erythematosus.[1]

ML323 is a potent selective inhibitor of the USP1–UAF1 deubiquitinase complex with an IC₅₀ of 76 nM in a ubiquitin-rhodamine (Ub-Rho) assay and excellent selectivity against other human deubiquitinases (DUBs), deSUMOylase, deneddylase and unrelated proteases. Human ubiquitin-specific protease 1 (USP1) associated with UAF1 is involved in the DNA damage response in the DNA translesion synthesis and Fanconi anemia pathways as the DUB responsible for deubiquitinating PCNA, which allows DNA replication past DNA lesions, and FANCD2 and FANCI, which function in interstrand crosslink repair. ML323 was found to potentiate cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.

ML323 is a potent selective inhibitor of the USP1–UAF1 deubiquitinase complex.

その他情報

ML323 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the ML323 probe summary on the Chemical Probes Portal website.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable