SML0940

Nepicastat hydrochloride

≥95% (HPLC)

• 別名: 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride, SYN-117
• 実験式（ヒル表記法）: C₁₄H₁₅F₂N₃S · HCl
• CAS番号: 170151-24-3
• 分子量: 331.81
• NACRES: NA.77
• PubChem Substance ID: 329825620
• UNSPSC Code: 12352200
• MDL number: MFCD00954638
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

特性

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC1=CC2=C(CC[C@H](N3C(CN)=CNC3=S)C2)C(F)=C1.Cl
• InChI: 1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1
• InChI key: DIPDUAJWNBEVOY-PPHPATTJSA-N

詳細

Application

Nepicastat hydrochloride has been used as an inhibitor of dopamine β-hydroxylase (DBH) in zinc finger protein 521 (ZFP521) deficient mice.

Biochem/physiol Actions

Nepicastat is a potent and selective dopamine β-hydroxylase inhibitor

Nepicastat is a potent and selective dopamine β-hydroxylase inhibitor with an IC₅₀ of 9 nM and negligible affinity (>10 μM) for twelve other enzymes and thirteen neurotransmitter receptors tested. Nepicastat has been shown to attenuate multiple aspects of cocaine-seeking behavior and suppress cocaine-primed reinstatement of cocaine seeking in rats, and has been in clinical trials for cocaine dependence. Nepicastat also suppressed chocolate self-administration and reinstatement of chocolate seeking in rats.

By inhibiting dopamine β-hydroxylase (DβH), nepicastat enhances dopamine levels and norepinephrine levels in brain.

Features and Benefits

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安全性情報

• ピクトグラム: GHS07
• 注意喚起語: Warning
• ハザードコード: H315,H319,H335
• 注意事項: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標的臓器: Respiratory system
• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• 引火点 (F): Not applicable
• 引火点（°C）: Not applicable