SML0863

A-1070722

≥98% (HPLC)

• 別名: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
• 実験式（ヒル表記法）: C₁₇H₁₃F₃N₄O₂
• CAS番号: 1384424-80-9
• 分子量: 362.31
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 15 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)c1nc(ccc1)NC(=O)Nc2c3c(ncc2)cc(cc3)OC
• InChI: 1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)
• InChI Key: VQPBIJGXSXEOCU-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A-1070722 showed > 50-fold selectivity for GSK-3 over a panel of other kinases tested, including CDK family members. A-1070722 decreased phosphorylation of microtubule-associated protein Tau and protected rat primary cortical neurons against β amyloid and glutamate challenge.

A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms.

特徴および利点

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable