SML0720

メタゾラミド

≥98% (HPLC)

• 別名: N-(4-メチル-2-スルファモイル-Δ²-1,3,4-チアジアゾリン-5-イリデン)アセトアミド
• 実験式（ヒル表記法）: C₅H₈N₄O₃S₂
• CAS番号: 554-57-4
• 分子量: 236.27
• EC Number: 209-066-7
• MDL番号: MFCD00083416
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825590
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: protect from light
• 色: white to beige
• mp: 208 °C (dec.) (lit.)
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
• InChI: 1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
• InChI Key: FLOSMHQXBMRNHR-QPJJXVBHSA-N
• 遺伝子情報: human ... CA1(759) , CA2(760) , CA4(762) , CA7(766)

詳細

生物化学的／生理学的作用

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

その他情報

Light sensitive

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332,H351
• 注意書き: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3