SML0510

S 26948

≥98% (HPLC)

• 別名: 2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester, S26948
• 実験式（ヒル表記法）: C₂₈H₂₅NO₇S
• CAS番号: 353280-43-0
• 分子量: 519.57
• MDL番号: MFCD18086885
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825519
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL (clear solution)
• 保管温度: 2-8°C
• SMILES記法: COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC
• InChI: 1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3
• InChI Key: NSMJEHGOMXSLCW-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

S 26948 belongs to the non-thiazolidinedione (TZD) class of drugs. It has the potential to treat diabetes and atherogenesis.[1]

S 26948 is a partial PPARγ agonist; selective PPARγ modulator (SPPARγM).

S 26948 is a selective PPARγ modulator (SPPARγM). S 26948 is as effective as rosiglitazone in reducing insulin resistance and lipid homeostasis, but does not increase body or white adipose tissue weight. S 26948 also leads to different co-activatior recruitment to PPARγ than rosiglitazone.

特徴および利点

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable