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About This Item
実験式（ヒル表記法）:
C7H5ClO3
CAS番号:
分子量:
172.57
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
おすすめの製品
アッセイ
≥97% (HPLC)
フォーム
powder
色
white to beige
溶解性
DMSO: 15 mg/mL (clear solution)
保管温度
room temp
SMILES記法
Oc1cc(Cl)cc(c1)C(O)=O
InChI
1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11)
InChI Key
RJOLIYHZZKAIET-UHFFFAOYSA-N
生物化学的／生理学的作用
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81.
3-Chloro-5-hydroxybenzoic acid is a selective agonist of the lactate receptor, GPR81. Stimulation of either GPR81 or GPR109a in adipose tissue leads to a similar decrease in triglyceride lipolysis. Niacin is used to treat dyslipidemia via its agonism of GPR109a, but compliance is low due to side effects (flushing and pruritus), which are associated with GPR109a agonism. 3-Chloro-5-hydroxybenzoic acid is selective for GPR81 over other GPCRs, including GPR109a. While less potent than niacin (16 vs. 0.78 μM), it has similar activity as the same dose as niacin in animal studies and should not cause the flushing that is associated with niacin.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML0447-VAR:
SML0447-25MG:
SML0447-5MG:
SML0447-BULK:
最新バージョンのいずれかを選択してください：
Timothy P Brown et al.
Oncogene, 39(16), 3292-3304 (2020-02-20)
GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether lactate has any paracrine role via activation of GPR81 in
Marvin Lambertus et al.
Acta physiologica (Oxford, England), 231(3), e13587-e13587 (2020-11-28)
Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing
Rafaz Hoque et al.
Gastroenterology, 146(7), 1763-1774 (2014-03-25)
The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is known about its regulation. Toll-like receptors (TLRs) provide the first signal required for activation of the inflammasome and stimulate aerobic
Haíssa de Castro Abrantes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4422-4433 (2019-03-31)
The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. In this study, we characterized the intracellular pathways engaged by HCAR1
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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