SML0103

AMTB hydrate

≥98% (HPLC)

• 別名: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate
• 実験式（ヒル表記法）: C₂₃H₂₆N₂O₂S·HCl · xH₂O
• CAS番号: 926023-82-7
• 分子量: 430.99 (anhydrous basis)
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825160
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to tan
• 溶解性: DMSO: ≥10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
• InChI: 1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
• InChI Key: RTYVTAQFASBIDN-UHFFFAOYSA-N

詳細

アプリケーション

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells[1] and murine T cells.[2]

生物化学的／生理学的作用

AMTB is a 2-benzyloxy-benzoic acid amide derivative,[1] which also inhibits voltage-gated sodium channels (Nav) and their isoforms.[1]

AMTB is a TRPM8 ion channel blocker

AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable