SMB00314

Coptisine Chloride

≥98% (HPLC)

• 別名: Coptisine chloride, Bis(methylenedioxy)protoberberine chloride, Coptisin Chloride
• 実験式（ヒル表記法）: C₁₉H₁₄ClNO₄
• CAS番号: 6020-18-4
• 分子量: 355.77
• MDL番号: MFCD00016676
• UNSPSCコード: 12352205
• PubChem Substance ID: 329824946
• NACRES: NA.25

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C
• SMILES記法: C1(OCO2)=C2C=C(CC[N+]3=C4C=C5C(C(OCO6)=C6C=C5)=C3)C4=C1.[Cl-]
• InChI: 1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
• InChI Key: LUXPUVKJHVUJAV-UHFFFAOYSA-M

詳細

詳細

Coptisine chloride is a cytotoxic isoquinoline alkaloid. It is the major bioactive compound of Coptis rhizome, and can also be found in different plants such as Chelidonium majus, Enantia chlorantha. Coptisine is related to berberine and has a similar structure to that of Jatrorrhizine.

アプリケーション

Coptisine Chloride has been used to study its binding interactions with single-stranded poly(A) using different absorbance and thermal melting spectroscopic experiments. It may have been used as a standard to analyze Chelidonium majus L. extracted compounds using UV/VIS absorption spectroscopy.

生物化学的／生理学的作用

Coptisine Chloride is a potent anti-malarial compound, which also exerts anti-cancer and anti-diabetic properties. It elicits protective effects on gastric mucus membrane and is used as a traditional medicine against gastroenteric diseases. Coptisine chloride also displays anti-microbial activities.It has been analyzed as a cytotoxic agent in hepatoma and leukemic cells and is reported to block cell cycle progression.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300 + H330
• 注意書き: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• 危険有害性の分類: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable