SBR00041

Cefiderocol

• 別名: S-649266
• 実験式（ヒル表記法）: C₃₀H₃₄ClN₇O₁₀S₂
• CAS番号: 1225208-94-5
• 分子量: 752.21
• MDL番号: MFCD30533432
• UNSPSCコード: 12352111
• NACRES: NA.76

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• フォーム: solid
• 反応適合性: reagent type: chelator
• 抗生物質活性スペクトル: Gram-negative bacteria
• 作用機序: protein synthesis | inhibits
• 保管温度: −20°C
• SMILES記法: NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1
• InChI: 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
• InChI Key: DBPPRLRVDVJOCL-FQRUVTKNSA-N

詳細

詳細

Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.

Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266.[1][2] It has a catechol-type siderophore and cephalosporin core and side chains.[1] Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.[3]

アプリケーション

Cefiderocol has been used:

• study bacterial infections and tracking their uptake in vivo
• the study of the activity of Cefiderocol against gram-negative bacteria[1]

生物化学的／生理学的作用

Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens.[1][2] Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.[1]

特徴および利点

• High-quality antibiotic suitable for multiple research applications
• Ideal for Cell Biology and Biochemical research

その他情報

For additional information on our range of Biochemicals, please complete this form.

免責事項

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable