SAB4700432

Monoclonal Anti-CD46-PE antibody produced in mouse

clone MEM-258, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-Membrane Cofactor Protein
• UNSPSCコード: 12352203
• NACRES: NA.44

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: phycoerythrin (R-PE) conjugate
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-258, monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: bovine, human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_002389.4
• UniProtアクセッション番号: P15529
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CD46(4179)

詳細

詳細

The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.

The gene cluster of differentiation 46 (CD46) is localized in the regulators of complement activation gene cluster on human chromosome 1q32.2. The gene codes for a type 1 membrane bound protein called membrane cofactor protein (MCP). The encoded protein is characterized with an intracellular tail region with several variant structures such as, a single transmembrane α-helical region, a short region of unknown function (U), a collar STP-rich region and finally four extracellular complement control protein (CCP) domains involved in the cofactor activity. MCP is ubiquitously expressed.

免疫原

HPB-ALL human T cell line

アプリケーション

試薬は、100 μL全血または1e6細胞懸濁液につき20 μLの試薬を用いたヒト血液細胞のフローサイトメトリー解析用にデザインされています。バイアル（2 mL）の内容量は100回分です。

生物化学的／生理学的作用

Membrane cofactor protein (MCP) acts as a complement regulator and protects the cells from autologous complement-mediated damage. It plays a major role in inhibition of alternative pathway (AP), lectin pathway (LP) and classical pathway (CP). In addition, it also acts as a cellular receptor for certain pathogens such as the measles virus (Edmonston strain), human herpesvirus 6 and Neisseria gonorrhoeae. The encoded protein facilitates the fertilization of the human egg. Mutations in the CD46 gene has been observed in patients with preeclampsia and atypical hemolytic uremic syndrome (aHUS).

特徴および利点

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物理的形状

PBS（15 mM アジ化ナトリウム、安定化剤として0.2％ハイグレード プロテアーゼフリーBSA含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable