SAB4504621

Anti-phospho-MER/SKY (pTyr^749/681) antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 110 kDa
• 交差性: human, rat, mouse
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBIアクセッション番号: Q06418; Q12866
• UniProtアクセッション番号: Q06418
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr749/pTyr681)
• 遺伝子情報: human ... MERTK(10461) , TYRO3(7301)

詳細

詳細

Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.

免疫原

The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.

Immunogen Range: 716-765

生物化学的／生理学的作用

Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable