Anti-GAD1 antibody detects endogenous levels of total GAD1 protein.
GAD1 gene (glutamate decarboxylase 1) codes for a glutamic acid decarboxylase enzyme (GAD67), that is of 67 kDa. It is mapped to human chromosome 2q31.1.
免疫原
The antiserum was produced against synthesized peptide derived from human GAD1.
Immunogen Range: 471-520
生物化学的/生理学的作用
GAD1 gene (glutamate decarboxylase 1) participates in GABA (γ-aminobutyric acid) synthesis. Variations in GAD1 results in hyperactivity in attention-deficit/hyperactivity disorder. It is also characterized with childhood-onset schizophrenia and cortical gray matter volume loss.
特徴および利点
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物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis
Yee JY, et al.
PLoS ONE, 12(1), e0170805-e0170805 (2017)
GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder
Bruxel EM, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 171(8), 1099-1104 (2016)
GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss.