Anti-Collagen I α2 Antibody detects endogenous levels of total Collagen I α2 protein.
Collagen I α2 (COL1A2) is located on human chromosome 7q22.1. Human COL1A2 gene consists of two dinucleotide repeats: one in the 5′-flanking region of the gene, made of of poly(dC–dA) and poly(dC–dG) and the other in the first intron comprised of poly(dG–dT).
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen I alpha2.
Immunogen Range: 471-520
アプリケーション
Anti-Collagen I α2 antibody has been used to quantify protein expression levels after western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper)
生物化学的/生理学的作用
Collagen I α2 (COL1A2) is essential to maintain elasticity of the vessel wall and is an important constituent of the extracellular matrix. Mutations in COL1A2 results in osteogenesis imperfecta (OI).
特徴および利点
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物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.
Spotila LD, et al.
Proceedings of the National Academy of Sciences of the USA, 88(12), 5423-5427 (1991)
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population.
Tian DZ, et al.
Genetics and molecular research : GMR, 15(1) (2015)
Collagen type I ?2 (COL1A2) is the susceptible gene for intracranial aneurysms.
Cystic vestibular schwannoma (CVS) and solid vestibular schwannoma (SVS) are subgroups of vestibular schwannoma (VS). The tumorigenesis of CVS and SVS have not been fully elucidated, and this study is designed to identify differentially expressed proteins involved in the tumorigenesis
Angiotensin II increases fibronectin and collagen I through the ?-catenin-dependent signaling in mouse collecting duct cells.
Cuevas CA, et al.
American Journal of Physiology: Renal Physiology, 308(4), F358-F365 (2014)