SAB4300689

Anti-ABCG2 antibody produced in rabbit

affinity isolated antibody

• 別名: 抗MRX抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 65-80 kDa
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (R-I-N-R-V)
• NCBIアクセッション番号: NM_004827.2
• UniProtアクセッション番号: Q9UNQ0
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ABCG2(9429)

詳細

詳細

The ABCG2 (ATP binding cassette subfamily G member 2) gene encodes an ATP-binding cassette (ABC) transporter that is also called as breast cancer resistance protein (BRCP). It is composed of 655 amino-acids and is located on human chromosome 4q22. It belongs to the ABCG (white) subfamily.

The antibody detects endogenous level of total ABCG2(CD338) protein.

免疫原

Peptide sequence around aa. 160-164 ( R-I-N-R-V), according to the protein NP_004818.2

生物化学的／生理学的作用

ABCG2 (ATP binding cassette subfamily G member 2) serves as a shield for several tissues against xenobiotic molecules. It can provide multidrug resistance (MDR) in breast and other cell lines.

特徴および利点

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ターゲットの説明

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable