Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein found in the astrocytes of CNS (central nervous system).{56,59} It is located on chromosome 17q21.
The antibody detects endogenous level of total GFAP protein.
免疫原
Peptide sequence around aa. 423-427 (E-S-K-Q-E), according to the protein NP_002046.1
生物化学的/生理学的作用
Glial fibrillary acidic protein (GFAP) regulates intermediate filament network dynamics, cell morphology and focal adhesions. It helps in maintaining myelination and stability of CNS (central nervous system) white matter architecture.
特徴および利点
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ターゲットの説明
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
物理的形状
PBS(0.02% アジ化ナトリウム、50% グリセロール含有)
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(4), 1535-1559 (2018-10-31)
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GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination