SAB4300034

Anti-phospho-STAT3 (pSer⁷²⁷) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗APRF抗体 ウサギ宿主抗体, 抗FLJ20882抗体 ウサギ宿主抗体, 抗HIES抗体 ウサギ宿主抗体, 抗MGC16063抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: ~88 kDa
• 交差性: mouse, human, rat
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (P-M-SP-P-R)
• NCBIアクセッション番号: NP_003141.2
• UniProtアクセッション番号: P40763
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer727)
• 遺伝子情報: human ... STAT3(6774)

詳細

詳細

Signal transducer and activator of transcription 3 (STAT3), a constituent of the interleukin-6- (IL-6) activated acute phase response factor (APRF) complex, belongs to the signal transducer and activator of transcription (STAT) family. It is expressed in all types of tissues. The STAT3 gene with 24 exons is mapped to human chromosome 17q21.2.

免疫原

Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-R), according to the protein STAT3.

アプリケーション

Anti-phospho-STAT3 (pSer727) antibody produced in rabbit has been used in immunoblotting (1:1000) and immunofluorescence staining (1:200).[1][2][3][4]

生物化学的／生理学的作用

Signal transducer and activator of transcription 3 (STAT3) protein play a key role in cell growth, apoptosis, metabolism, cellular respiration, and autophagy. It may act as a co-activator of signal transduction by glucocorticoid receptors. STAT3 regulates transcription. It is involved in the development of vertebrates and the regulation of inflammation and immunity. It might participate in airway inflammation, allergy, and asthma. Mutations in the STAT3 gene are associated with immunodeficiency, autoimmunity, and cancer.

特徴および利点

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ターゲットの説明

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable