Glucose transporter 1 (GLUT1, SLC2A1) belongs to the family of glucose transporters (GLUTs). It is localized to the membrane and is highly expressed in the brain and spinal cord, with a relative high density in the cerebellum. The vascular form of GLUT1 is mainly localized in endothelial cells of blood vessels.
免疫原
peptide corresponding to a sequence at the C-terminus of human GLUT1, conjugated to KLH. The corresponding sequence is identical in rat and mouse GLUT1.
アプリケーション
Anti-GLUT1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生物化学的／生理学的作用
GLUT1 is the main glucose transporter in the blood-brain barrier (BBB), which regulates basal glucose levels. Increased expression of GLUT1 is associated with cell growth and in malignant transformation.
物理的形状
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
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Immunohistochemical localization and quantification of glucose transporters in the mouse brain
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Differential localization of glucose transporter isoforms in non-polarized mammalian cells: distribution of GLUT1 but not GLUT3 to detergent-resistant membrane domains
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Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin
