SAB4200034

Anti-BMI1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-B lymphoma Mo-MLV insertion region 1 homolog, Anti-PCGF4, Anti-Polycomb group RING finger protein 4, Anti-RNF51, Anti-Ring finger protein 51
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous glycerol solution
• 分子量: antigen ~37 kDa
• 交差性: human
• 包装: antibody small pack of 25 μL
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human BMI1; indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human BMI1; western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human BMI1
• UniProtアクセッション番号: P35226
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... BMI1(648)

詳細

詳細

Anti-BMI1 (C-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the C-terminal of human BMI1, conjugated to KLH. The human proto-oncogene BMI1 (also known as polycomb complex protein BMI-1, polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

アプリケーション

Anti-BMI1 (C-terminal) antibody produced in rabbit has been used in:

• western blotting[1]
• immunoprecipitation
• immunofluorescence

生物化学的／生理学的作用

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable