SAB2702004

Anti-PPP1CB antibody produced in rabbit

• 別名: PP-1B, PP1B, PP1beta, PPP1CD
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: liquid
• 分子量: 37 kDa
• 交差性: human, mouse
• 濃度: 0.5 mg/mL
• テクニック: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 500-3000
• UniProtアクセッション番号: P62140
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... PPP1CB(5500)

詳細

詳細

Protein phosphatase 1 catalytic subunit β (PPP1CB) gene is mapped to human chromosome 2p23.2. It is expressed in spines, dendrites, axon terminals, axons and glia in the prefrontal cortex. PPP1CB is expressed at higher levels in dendrites. It has a calcineurin-like phosphoesterase domain, a metallophosphatase domain and a serine/threonine protein phosphatase domain.

免疫原

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 274 of PPP1CB

アプリケーション

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生物化学的／生理学的作用

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
In the brain, protein phosphatase 1 catalytic subunit β (PPP1CB) regulates synaptic plasticity. Mutation in the gene causes intellectual disability (ID), congenital heart disease.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317,H412
• 注意書き: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危険有害性の分類: Aquatic Chronic 3 - Skin Sens. 1
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable