おすすめの製品
由来生物
mouse
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~33.4 kDa
化学種の反応性
human
テクニック
indirect immunofluorescence: suitable
western blot: 1 μg/mL
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PYCR1(5831)
詳細
Pyrroline-5-carboxylate reductase 1 (PYCR1) is a housekeeping gene.The gene is located on human chromosome 17q25.3.
免疫原
PYCR1 (NP_008838.2, 1 a.a. ~ 319 a.a) full-length human protein.
Sequence
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
Sequence
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
生物化学的／生理学的作用
Pyrroline-5-carboxylate reductase 1 (PYCR1) acts as a prognostic biomarker for breast cancer.Mutations in this gene affects mitochondrial function and is associated with connective tissue disorder cutis laxa.It helps in cell metabolism.This protein catalyses the conversion of 1-piperideine-6-carboxylate (P6C) into pipecolic acid.
物理的形状
無色透明のPBS溶液、pH 7.4
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers
Ding, Ji , et al.
Carcinogenesis, 38(5), 519-531 (2017)
Human pyrroline-5-carboxylate reductase (PYCR1) acts on Delta 1-piperideine-6-carboxylate generating L-pipecolic acid
Struys,, et al.
Journal of inherited metabolic disease, 37(3), 327-332 (2014)
Improving the prediction accuracy in classification using the combined data sets by ranks of gene expressions
Kim, Ki, et al.
BMC Bioinformatics, 9(1), 283-283 (2008)
Resolving the cofactor binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1
Christen, et al.
Test, jbc-M117 (2017)
Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer
Zeng, Te, et al.
Medical Oncology (Northwood, London, England), 34(2), 27-27 (2017)
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