SU 4312 was used to study angiogenesis during development of zebrafish embryos.2
生物化学的／生理学的作用
SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.
特徴および利点
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その他情報
This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(3), 656-663 (2009-02-25)
Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical screens, and optical transparency makes them potentially suited for image-based screening. However, the lack of
British journal of pharmacology, 168(5), 1201-1214 (2012-10-16)
SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection by SU4312 against 1-methyl-4-phenylpyridinium
