S5637

スルファメタジン ナトリウム塩

≥98%

• 別名: 4-アミノ-N-(4,6-ジメチル-2-ピリミジニル)ベンゼンスルホンアミド
• 化学式: C₁₂H₁₃N₄O₂SNa
• CAS番号: 1981-58-4
• 分子量: 300.31
• EC Number: 217-840-0
• MDL番号: MFCD00068333
• UNSPSCコード: 51284910
• PubChem Substance ID: 24899666
• NACRES: NA.85

特性

• 品質水準: 200
• アッセイ: ≥98%
• 形状: powder
• 保管条件: (Keep container tightly closed in a dry and well-ventilated place.)
• 色: white to off-white
• 溶解性: H₂O: soluble 50 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; enzyme | inhibits
• 保管温度: 2-8°C
• SMILES記法: [Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
• InChI: 1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
• InChI Key: WIVZAHIZHZEEOX-UHFFFAOYSA-N

詳細

詳細

Chemical structure: sulfonamide

アプリケーション

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine.

生物化学的／生理学的作用

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

包装

25G,100G

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable