おすすめの製品
アッセイ
~85%
フォーム
powder
色
yellow to greenish yellow
抗生物質活性スペクトル
neoplastics
作用機序
enzyme | interferes
SMILES記法
CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[N+]([O-])=O
InChI
1S/C14H13N3O5S/c1-10(18)15-11-4-8-14(9-5-11)23(21,22)16-12-2-6-13(7-3-12)17(19)20/h2-9,16H,1H3,(H,15,18)
InChI Key
GWBPFRGXNGPPMF-UHFFFAOYSA-N
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アプリケーション
Sulfanitran is used to stimulate MRP2. It is used to stimulate the MRP2-mediated transport of lipophilic amphipathic drugs. It is used to study the efflux of chemotherapeutics in tumor cell lines.
生物化学的/生理学的作用
Sulfanitran stimulates the ATP binding cassette family transporter multidrug resistance protein 2 (MRP2). Sulfanitran increases the affinity of MRP2 for estradiol-17-β-D-glucuronide. It stimulates the vectorial transport of saquinavir, a MRP2 substrate, across polarized MDCKII monolayers.
その他情報
Keep container tightly closed in a dry and well-ventilated place.
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
S5272-BULK:
S5272-5G:
S5272-25G:
S5272-100G:
S5272-VAR:
最新バージョンのいずれかを選択してください:
Drug metabolism and disposition: the biological fate of chemicals, 37(1), 129-136 (2008-10-11)
Diclofenac is an important analgesic and anti-inflammatory drug, widely used for treatment of postoperative pain, rheumatoid arthritis, and chronic pain associated with cancer. Consequently, diclofenac is often used in combination regimens and undesirable drug-drug interactions may occur. Because many drug-drug
The Journal of biological chemistry, 278(26), 23538-23544 (2003-04-19)
Multidrug resistance protein 2 (MRP2) belongs to the ATP binding cassette family of transporters. Its substrates include organic anions and anticancer drugs. We have used transport assays with vesicles derived from Sf9 insect cells overproducing MRP2 to study the interactions
International journal of pharmaceutics, 381(2), 199-204 (2009-09-29)
Intestinal efflux transporters can significantly reduce the absorption of the drug after peroral application. In this work we studied secretion of glutathione conjugates triggered by glucose at the luminal side of the intestine. Glucose stimulated secretion of DNPSG, NEMSG and
Se pu = Chinese journal of chromatography, 25(2), 238-240 (2007-06-22)
A method for the determination of 12 sulfonamides (SAs) (sulfanilamide, sulfamonomethoxine, sulfacetamide, sulfamethoxazole, sulfadiazine, sulfisoxazole, sulfathiazole, sulfadi-methoxine, sulfamerazine, sulfaquinoxaline, sulfamethazine, sulfanitran) in cosmetics was developed by ultra performance liquid chromatography with photodiode array detector (UPLC-PDA). The chromatographic column used was
Analytical and bioanalytical chemistry, 407(15), 4423-4435 (2014-12-30)
Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical method to monitor up to 131
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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