R9156

ラルチトレキセド 一水和物

≥98% (HPLC), solid

• 別名: L-グルタミン酸, N-((5-(((1,4-ジヒドロ-2-メチル-4-オキソ-6-キナゾリニル)メチル)メチルアミノ)-2-チエニル)カルボニル)- 一水和物, ICI-D-1694, ZD-1694
• 実験式（ヒル表記法）: C₂₁H₂₂N₄O₆S
• CAS番号: 112887-68-0
• 分子量: 458.49
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824044
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: off-white to light yellow
• 溶解性: H₂O: ≥10 mg/mL; DMSO: ≥40 mg/mL
• オーガナイザー: AstraZeneca
• 保管温度: 2-8°C
• SMILES記法: O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

詳細

生物化学的／生理学的作用

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

特徴および利点

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H300,H360
• 注意書き: P201 - P301 + P310 + P330
• 危険有害性の分類: Acute Tox. 2 Oral - Repr. 1B
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges