R0533

Rifapentine

• 別名: 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, Cyclopentylrifampicin, DL 473
• 実験式（ヒル表記法）: C₄₇H₆₄N₄O₁₂
• CAS番号: 61379-65-5
• 分子量: 877.03
• EC Number: 262-743-9
• UNSPSCコード: 51283603
• PubChem Substance ID: 329823987
• NACRES: NA.85

特性

• アッセイ: ≥93.5%
• 形状: powder or crystals
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用機序: enzyme | inhibits
• 輸送温度: wet ice
• 保管温度: 2-8°C
• InChI: 1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23?/t24-,26+,27+,28+,33?,38-,39+,43+,47-/m0/s1
• InChI Key: WDZCUPBHRAEYDL-OABFQHKQSA-N

詳細

詳細

Chemical structure: macrolide

アプリケーション

Rifapentine is an antibiotic clinically used to treat tuberculosis. It is used in tuberculosis research.

生物化学的／生理学的作用

Rifapentine is a semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacteria and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription. It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacterial and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription.

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable