PZ0198

Prinomastat hydrochloride

≥95% (HPLC)

• 別名: (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride, AG 3340 hydrochloride, AG-3340 hydrochloride, AG3340 hydrochloride
• 実験式（ヒル表記法）: C₁₈H₂₁N₃O₅S₂ · HCl
• CAS番号: 192329-42-3
• 分子量: 459.97
• UNSPSCコード: 12352200
• PubChem Substance ID: 329823770
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 15 mg/mL (clear solution)
• 保管温度: room temp
• SMILES記法: Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
• InChI: 1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
• InChI Key: UQGWXXLNXBRNBU-NTISSMGPSA-N

詳細

詳細

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.[1]

アプリケーション

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples[2] and mouse embryo cultures.[3] It may be used as a MMP-2 inhibitor in HepG2 cells.[4]

生物化学的／生理学的作用

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC₅₀s, 30 pM & 50 pM, respectively.

Prinomastat is a matrix metalloprotease (MMP) inhibitor.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H360
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable