Nicastrin (NCSTN) is a transmembrane glycoprotein, that is located on chromosome 1q23.
免疫原
a 18 amino acid peptide from near the center of human Nicastrin.
アプリケーション
Anti-Nicastrin has been used in western blotting.
生物化学的/生理学的作用
Nicastrin (NCSTN) helps in the assembly of γ-secretase complex. It is associated with Alzheimer′s disease.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3985.
物理的形状
PBS溶液(0.02%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
Dermaut B, et al.
American Journal of Human Genetics, 70(6), 1568-1574 (2002)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular events underlying