RuvB-like 2 (RUVBL2), a transcription factor, belongs to the AAA+ protein subfamily of conserved ATPases linked with diverse cellular functions. A distinctive domain II (DII) protrudes from one side of the hexamer and defines two separate faces of the ring in RUVBL2.
免疫原
The epitope recognized by PLA0259 maps to a region between residue 1 and 50 of human RuvB-like 2 using the numbering given in entry NP_006657.1 (GeneID 10856).
生物化学的／生理学的作用
RuvB-like 2 (RUVBL2) plays a regulatory role in the Fanconia anemia (FA) pathway, the assembly of the telomerase holoenzyme, and nonsense-mediated mRNA decay (NMD). It may play a role in tumorigenesis and cancer progression. Overexpression of the RUVBL2 protein is observed in hepatocellular carcinoma (HCC), renal cell carcinoma, colorectal cancer, gastric cancer, breast cancer, and salivary gland cancer. It can be used as a promising target for preventing and treating HCC.
物理的形状
トリスクエン酸／リン酸塩緩衝液、pH 7～8、0.09％ アジ化ナトリウム含有
その他情報
RuvB-like 2 (RuvBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities [taken from NCBI Entrez Gene (GeneID: 9400)].
免責事項
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Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of several macromolecular complexes such
