P5390

Prostaglandin B₂

≥98%, synthetic

• 別名: (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid, PGB₂
• 実験式（ヒル表記法）: C₂₀H₃₀O₄
• CAS番号: 13367-85-6
• 分子量: 334.45
• Beilstein: 2153006
• MDL番号: MFCD00065730
• UNSPSCコード: 12352211
• PubChem Substance ID: 24898630
• NACRES: NA.77

特性

• 由来生物: synthetic
• 品質水準: 100
• アッセイ: ≥98%
• 形状: solution
• 溶解性: ethanol: ~100 mg/mL; PBS, pH 7.2: ~2 mg/mL; DMSO: ~50 mg/mL
• 保管温度: −20°C
• SMILES記法: CCCCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1
• InChI: 1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1
• InChI Key: PRFXRIUZNKLRHM-HKVRTXJWSA-N

詳細

アプリケーション

Prostaglandin B2 has been used as an internal standard in high-performance liquid chromatography (HPLC).

生物化学的／生理学的作用

Prostaglandin B2 (PGB2) is an eicosanoid and a lipid mediator. It is synthesized by the dehydration of PGE2. It is a primary prostaglandin associated with the osteoblasts and may induce pulmonary hypertension. PGB2 is also reported to inhibit glucagon stimulated glycogenolysis and forskolin-stimulated adenylate cyclase activity in plasma membranes.

物理的形状

Prostaglandin B₂ is supplied as a solution in methyl acetate

調製ノート

PGB₂ is provided as a solution in methyl acetate. To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. PGB₂, purged with an inert gas, is soluble in ethanol at ~100 mg/mL, DMSO at ~50 mg/mL and in dimethyl formamide at ~ 75 mg/mL.

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H319,H336
• 注意書き: P210 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 補足的ハザード: EUH066
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 15.8 °F
• 引火点(℃): -9 °C
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter