Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.
免疫原
peptide corresponding to amino acid residues 125-142 of human P2Y12. This epitope is highly homologous in rat and mouse (16/18 residues identical).
アプリケーション
Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.
生物化学的／生理学的作用
Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.
物理的形状
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
免責事項
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