P4532

(−)-N⁶-(2-フェニルイソプロピル)アデノシン

solid

• 別名: (R)-N⁶-(1-メチル-2-フェニルエチル)アデノシン, N⁶-(L-2-フェニルイソプロピル)アデノシン, R-(−)-PIA
• 実験式（ヒル表記法）: C₁₉H₂₃N₅O₄
• CAS番号: 38594-96-6
• 分子量: 385.42
• EC Number: 254-028-5
• MDL番号: MFCD00069194
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277681
• NACRES: NA.77

特性

• 形状: solid
• 品質水準: 200
• 有効性: 1.17 nM K_i for A₁ receptors (using [³H]CHA in rat forebrain preparations)
• 色: white
• 溶解性: H₂O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.); 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
• 保管温度: 2-8°C
• SMILES記法: C[C@H](Cc1ccccc1)Nc2ncnc3n(cnc23)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
• InChI: 1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
• InChI Key: RIRGCFBBHQEQQH-SSFGXONLSA-N
• 遺伝子情報: human ... ADORA1(134)

詳細

生物化学的／生理学的作用

A₁ adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

特徴および利点

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)