K0515

Anti-Potassium Channel Kv12.1 (Elk1) ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: Anti-KCNH8, Anti-Voltage gated K⁺ channel subfamily H member 8, Anti-ether-a-go-go like K⁺ channel 3
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 交差性: rat
• テクニック: western blot: 1:200 using rat cortex lysates
• UniProtアクセッション番号: Q9QWS8
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rat ... Kcnh8(246325)

詳細

詳細

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.

免疫原

peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat K_V12.1.

生物化学的／生理学的作用

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.

ターゲットの説明

K_v12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the K_v12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.

物理的形状

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

再構成

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H312,H412
• 注意書き: P280
• 危険有害性の分類: Acute Tox. 4 Dermal - Aquatic Chronic 3
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable