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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
製品種目
Prestige Antibodies® Powered by Atlas Antibodies
フォーム
buffered aqueous glycerol solution
交差性
human
テクニック
immunohistochemistry: 1:20- 1:50
免疫原配列
SSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CYP1B1(1545)
詳細
The Cytochrome P4501B1 (CYP1B1) gene with three exons and two introns is mapped to human chromosome 2p21-22. The 543 amino acid protein encoded by this gene is expressed mainly in the adrenals, ovary. The protein is a member of cytochrome P4501, a subfamily of CYP1 family .
CYP1B1 is deprived of a consensus TATA box in the promoter region and it is characterized with nine tetrachlorodibenzo-p-dioxin (TCDD) responsive enhancer core binding motifs present within a 2.5kb pair genomic fragment of the transcription initiation start site.
CYP1B1 is deprived of a consensus TATA box in the promoter region and it is characterized with nine tetrachlorodibenzo-p-dioxin (TCDD) responsive enhancer core binding motifs present within a 2.5kb pair genomic fragment of the transcription initiation start site.
免疫原
シトクロムP450ファミリー1サブファミリーBポリペプチド1のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。
アプリケーション
Prestige抗体®は、Human Proteome Resource(HPR)プロジェクト (www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験の プロトコール およびPrestige抗体、HPAに関する情報は sigma.com/prestigeをご覧ください。
生物化学的／生理学的作用
Tissue distribution pattern analysis shows that cytochrome P4501B1 (CYP1B1) plays a vital role in metabolism of xenobiotics and possibly steroid hormones. CYP1B1 might be responsible for the metabolism of biologically active molecule associated with eye development. Any truncating mutation of the gene coding for this protein causes primary congenital glaucoma. Isoflavone genistein stimulates the gene expression of CYP1B1, which plays a vital role in human breast cancer development and progression. CYP1B1 enzyme catalyzes the conversion of pro-carcinogens to carcinogens and also facilitates estrogen metabolism. Single nucleotide polymorphism (SNP) of CYP1B1 might enhance susceptibility and pathological development of hepatocellular carcinoma (HCC) in Chinese population.
特徴および利点
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
関連事項
Corresponding Antigen APREST86682
物理的形状
PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。
法的情報
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
HPA026863-25UL:
HPA026863-100UL:
最新バージョンのいずれかを選択してください：
Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21.
Human Molecular Genetics, 6(4), 641-647 (1997)
Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells.
Wei YK
Journal of Environmental Pathology, Toxicology and Oncology, 34(2), 153-159 (2015)
Isolation and characterization of the human cytochrome P450 CYP1B1 gene.
Tang YM
The Journal of Biological Chemistry, 271(45), 28324-28330 (1996)
Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.
Liu F
Gene, 564(1), 14-20 (2015)
Carla A Piccinato et al.
Reproduction (Cambridge, England), 151(6), 683-692 (2016-03-26)
Endometriosis is an estrogen-dependent disease affecting up to 10% of all premenopausal women. There is evidence that different endometriosis sites show distinct local estrogen concentration, which, in turn, might be due to a unique local estrogen metabolism. We aimed to
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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