H7779

レチノイン酸 p-ヒドロキシアニリド

≥95%

• 別名: 4-HPR, N-(4-ヒドロキシフェニル)レチンアミド, フェンレチニド
• 実験式（ヒル表記法）: C₂₆H₃₃NO₂
• CAS番号: 65646-68-6
• 分子量: 391.55
• MDL番号: MFCD00792674
• UNSPSCコード: 12352106
• PubChem Substance ID: 24278472
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• アッセイ: ≥95%
• 形状: powder
• 色: yellow to yellow-orange
• 保管温度: −20°C
• SMILES記法: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
• InChI: 1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
• InChI Key: AKJHMTWEGVYYSE-FXILSDISSA-N

詳細

詳細

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

アプリケーション

Retinoic acid p-hydroxyanilide has been used:

• as a synthetic retinoid to induce apoptosis in SEB-1 sebocytes
• as a medium supplement for C2C12 myoblasts to test its effect on ceramide formation
• to test in cytotoxicity in T-cell acute lymphoblastic leukemia (T-ALL)

生物化学的／生理学的作用

Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis. It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis. Fenretinide may elicit anticancer activity in cultured human breast cancer cells. It acts as an insulin antagonist and may be useful in treating insulin resistance. Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302 + H312 + H332,H315,H319,H335,H360
• 注意書き: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges