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由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
>97% (SDS-PAGE)
フォーム
lyophilized powder
有効性
0.25-1.0 mg
分子量
~8.2 kDa
包装
pkg of 25 μg
保管条件
avoid repeated freeze/thaw cycles
テクニック
cell culture | mammalian: suitable
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... CCL26(10344)
関連するカテゴリー
詳細
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3.[1] This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids.[2] It belongs to the small inducible cytokine subfamily A [3], which also includes eotaxin and eotaxin-2.[4]
生物化学的／生理学的作用
Also known as CCL26 or SCYA26; a human CC chemokine and a functional ligand for CC chemokine receptor 3; mature recombinant human eotaxin-3 demonstrates chemotactic activity for eosinophils.
Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases.[2] As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma.[1] Demethylation results in increased expression of this gene, which in turn influences allergic reactions.[5] This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP.[4] Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.[6]
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.
物理的形状
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
アナリシスノート
The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Inhalation - Eye Irrit. 2
保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
E8399-25UG-PW:
E8399-BULK:
E8399-25UG:4548173948881
E8399-VAR:
Eunjin Lim et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 466-474 (2013-12-11)
DNA demethylation has been primarily studied in the context of development biology, cell fate, and cancer, with less attention on inflammation. In this article, we investigate the association between DNA methylation and production of the chemoattractant cytokine eotaxin-3 in the
A Shinkai et al.
Journal of immunology (Baltimore, Md. : 1950), 163(3), 1602-1610 (1999-07-22)
IL-4 has been shown to be involved in the accumulation of leukocytes, especially eosinophils, at sites of inflammation by acting on vascular endothelial cells. To identify novel molecules involved in the IL-4-dependent eosinophil extravasation, cDNA prepared from HUVEC stimulated with
K Takahashi et al.
Clinical and experimental immunology, 173(2), 323-331 (2013-04-24)
Eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3). In this study, we investigated eotaxin-3/CC chemokine ligand 26 (CCL26) expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and
M Kitaura et al.
The Journal of biological chemistry, 274(39), 27975-27980 (1999-09-17)
Previously, we mapped the novel CC chemokine myeloid progenitor inhibitory factor 2 (MPIF-2)/eotaxin-2 to chromosome 7q11.23 (Nomiyama, H., Osborne, L. R., Imai, T., Kusuda, J., Miura, R., Tsui, L.-C., and Yoshie, O. (1998) Genomics 49, 339-340). Since chemokine genes tend
C Günther et al.
Clinical and experimental immunology, 166(2), 145-153 (2011-10-12)
Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and
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